Abstract
Macrophage activation syndrome (MAS) - is a severe life-threatening hematological condition, complicated different rheumatic diseases. MAS is characterized by uncontrolled proliferation of T cells and macrophages, associated with decreased natural killer (NK) cells and cytotoxic T cell function due to mutations in perforin gene.
Highlights
Macrophage activation syndrome (MAS) - is a severe lifethreatening hematological condition, complicated different rheumatic diseases
MAS is characterized by uncontrolled proliferation of T cells and macrophages, associated with decreased natural killer (NK) cells and cytotoxic T cell function due to mutations in perforin gene
Medical charts of children with definite MAS who were admitted to our rheumatology department in 2005-2013 were reviewed
Summary
Macrophage activation syndrome (MAS) - is a severe lifethreatening hematological condition, complicated different rheumatic diseases. MAS is characterized by uncontrolled proliferation of T cells and macrophages, associated with decreased natural killer (NK) cells and cytotoxic T cell function due to mutations in perforin gene
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