PReS-FINAL-2152: Biomarkers as predictors of early inactive disease in children with juvenile idiopathic arthritis

Abstract

Results After a 12 months follow-up, 106 children were diagnosed with inactive and 85 children with active disease. Of the biomarkers measured in sera collected at inclusion, only a higher ESR at baseline (median 27 vs. 19 mm/h, p = 0.013) was significantly associated with a persistently active disease at 12 months follow-up. While none of the cytokine levels revealed significant differences, both MRP8/14 (median 1,145 vs. 815 ng/ml, p = 0.041) and S100A12 levels (120 vs. 87 ng/ml, p = 0.032) in sera collected after 3 months of specialized care were significantly higher in patients who did not reach inactive disease status after 12 months. ROC analyses for MRP8/14 (area under curve, AUC 0.618, 95% CI 0.510-0.726, p = 0.041) and for S100A12 (AUC 0.651, 95% CI 0.514-0.717, p = 0.033) revealed a moderate but robust predictive power of these biomarkers.