Abstract
Results After a 12 months follow-up, 106 children were diagnosed with inactive and 85 children with active disease. Of the biomarkers measured in sera collected at inclusion, only a higher ESR at baseline (median 27 vs. 19 mm/h, p = 0.013) was significantly associated with a persistently active disease at 12 months follow-up. While none of the cytokine levels revealed significant differences, both MRP8/14 (median 1,145 vs. 815 ng/ml, p = 0.041) and S100A12 levels (120 vs. 87 ng/ml, p = 0.032) in sera collected after 3 months of specialized care were significantly higher in patients who did not reach inactive disease status after 12 months. ROC analyses for MRP8/14 (area under curve, AUC 0.618, 95% CI 0.510-0.726, p = 0.041) and for S100A12 (AUC 0.651, 95% CI 0.514-0.717, p = 0.033) revealed a moderate but robust predictive power of these biomarkers.
Highlights
The outcome of children with juvenile idiopathic arthritis (JIA) has improved over the last decades
In the German prospective controlled observational multicentre study ICON-JIA (Inception Cohort Of Newly-diagnosed patients with JIA) patients with diagnosis of JIA
Sera were collected from 191 children (132 girls, 59 boys), with JIA diagnosis based on the ILAR classification with a median age of 5 years
Summary
The outcome of children with juvenile idiopathic arthritis (JIA) has improved over the last decades. The disease course is still not easy to predict, especially based on traditional clinical factors. In the German prospective controlled observational multicentre study ICON-JIA (Inception Cohort Of Newly-diagnosed patients with JIA) patients with diagnosis of JIA
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