PReS-FINAL-2085: The p38-mediated rapid downregulation of cell surface gp130 expression impairs IL-6 signaling in the synovial fluid of juvenile idiopathic arthritis patients

N Honke,K Ohl,N Wagner,K Tenbrock,S Wüller,A Wiener

doi:10.1186/1546-0096-11-s2-p97

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https://doi.org/10.1186/1546-0096-11-s2-p97

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Abstract

In patients with juvenile idiopathic arthritis (JIA) high levels of IL-6 are present in the serum and synovial fluid (SF). IL-6 signaling plays an important pro-inflammatory role but is restricted by regulatory mechanisms such as reducing the cell surface availability of the signal-transducing chain of the IL-6 receptor (gp130).

Highlights

In patients with juvenile idiopathic arthritis (JIA) high levels of IL-6 are present in the serum and synovial fluid (SF)
Pediatric Rheumatology European Society (PReS)-FINAL-2085: The p38-mediated rapid downregulation of cell surface gp130 expression impairs IL-6 signaling in the synovial fluid of juvenile idiopathic arthritis patients
The results suggest that p38-mediated pro-inflammatory stimuli induce the downregulation of gp130 on monocytes and restrict gp130-mediated signal transduction

Summary

Introduction

In patients with juvenile idiopathic arthritis (JIA) high levels of IL-6 are present in the serum and synovial fluid (SF). PReS-FINAL-2085: The p38-mediated rapid downregulation of cell surface gp130 expression impairs IL-6 signaling in the synovial fluid of juvenile idiopathic arthritis patients N Honke*, K Ohl, A Wiener, N Wagner, S Wüller, K Tenbrock From 20th Pediatric Rheumatology European Society (PReS) Congress Ljubljana, Slovenia.

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