Abstract
compare with HLA B27+ and systemic onset arthritis. Level of IL-17A IL-1b, IL-6 (in contrast with tnfa level), was increased in patients with active HLA B27+ arthritis, if compare with other subtypes of JIA (p < 0,05). In patients with complete clinical and laboratory remission level of IL-17+T cells was reduced and almost did not differ from the control group. We also found statistically significant correlation between IL-6 level, RO+CCR6+ and the presence of osteoporosis in children with JIA. During therapy with tocilizumab expression of CCR6 and CCR4 on PBMC was decreased in patients with systemic onset JIA. Conclusion
Highlights
According to modern concepts of JIA as seen as generalizing term that brings together a heterogeneous group of chronic diseases of joints with different etiology, pathogenesis and immunogenetic origin, different nosology and controversial prognosis.Population of Th17 cells involved in pathogenesis of many autoimmune and chronic diseases due to the ability to destroy extracellular matrix
Pediatric Rheumatology European Society (PReS)-FINAL-2059: Th17 cells highly enriched in peripheral blood in children with HLA B27-associated arthritis and systemic onset juvenile idiopathic arthritis
Highest level of IL-17+T cells in peripheral blood was determined in children with active HLA B27 associated arthritis (p = 0,002) and systemic onset JIA (p = 0,005)
Summary
According to modern concepts of JIA as seen as generalizing term that brings together a heterogeneous group of chronic diseases of joints with different etiology, pathogenesis and immunogenetic origin, different nosology and controversial prognosis. Population of Th17 cells involved in pathogenesis of many autoimmune and chronic diseases due to the ability to destroy extracellular matrix
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
