Abstract
Systemic juvenile idiopathic arthritis (JIA) is a subtype of childhood arthritis associated with significant systemic inflammation as well as arthritis. Hyaluronic acid as a constituent of connective tissue has previously been described as a marker for arthritis in JIA in an Asian population. Mutations in hyaluronic acid synthase 2 leading to accumulation of hyaluronic acid have been found to be associated with a periodic fever syndrome in Shar-Pei dogs. Hyaluronic acid has therefore been suspected as a risk factor for systemic inflammation in humans.
Highlights
Systemic juvenile idiopathic arthritis (JIA) is a subtype of childhood arthritis associated with significant systemic inflammation as well as arthritis
25 patients were included in the study, of which 13 had active arthritis and 3 active systemic symptoms at time of sampling. 48% were treated with prednisone, 76% with a DMARD and 72% with a biologic drug at time of sampling
Patients with active arthritis had a mean level of hyaluronic acid of 180.5 μg/l, compared to 48.1 mg/l in patients without active arthritis (p = 0.002)
Summary
Systemic juvenile idiopathic arthritis (JIA) is a subtype of childhood arthritis associated with significant systemic inflammation as well as arthritis. Hyaluronic acid as a constituent of connective tissue has previously been described as a marker for arthritis in JIA in an Asian population. Mutations in hyaluronic acid synthase 2 leading to accumulation of hyaluronic acid have been found to be associated with a periodic fever syndrome in Shar-Pei dogs. Hyaluronic acid has been suspected as a risk factor for systemic inflammation in humans
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