Abstract
One of the major challenges in the management of juvenile dermatomyositis (JDM) is to accurately assess disease activity in order to optimize therapeutic strategies. Whole-body(WB)-MRI enables a reliable analysis of the site (skeletal muscle, subcutaneous tissue, myofascia) and magnitude of inflammatory process throughout the entire body. By providing an accurate estimation of the total disease activity load, this technique could be useful to tailor treatment according to disease severity.
Highlights
One of the major challenges in the management of juvenile dermatomyositis (JDM) is to accurately assess disease activity in order to optimize therapeutic strategies
Four patients were treated with prednisone alone, while the others received prednisone in different combinations with methotrexate (N = 15) or cyclosporine (N = 2)
WB-MRI muscular score was significantly higher in non-responders compared to the responders (34.5; IQR 18-55 p = 0.001)
Summary
One of the major challenges in the management of juvenile dermatomyositis (JDM) is to accurately assess disease activity in order to optimize therapeutic strategies. By providing an accurate estimation of the total disease activity load, this technique could be useful to tailor treatment according to disease severity
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