Prerenal proteinuria. III. Electrophoretic studies.

Abstract

ELECTROPHORETIC studies were carried out on the proteins from serum and urine of patients who suffered from what has been described previously as prerenal proteinuria. 1 In each case the rate of protein excretion was very large. Two patients were followed for six months or more during both exacerbation and remissions of their disease. During episodes of proteinuria, two albumins, split globulins and a low gamma globulin were found in either the serum or the urine, and sometimes in both. The reappearance of the albumin as a single fraction was the first sign of recovery from the proteinuria, the split globulin persisting until the edema was gone. Abnormalities of the electrophoretic pattern of the serum proteins of the one patient studied in this respect were lessened by the addition of human gamma globulin to the serum. EXPERIMENTAL METHODS AND RESULTS Method. —The serum to be studied was diluted to about