Prerectal mucinous cystadenoma. A case report and considerations about its origin

Jaime Zuloaga,Cristina Diaz-Del-Arco,Maria Jesus Fernandez-Aceñero,Javier Arias-Diaz,Julio Mayol,Antonio Torres

doi:10.21276/apalm.1453

Abstract

Mucinous cystadenoma is a generic denomination usually applied to cystic formations filled with mucinous content and showing signs of epithelial proliferation. They usually arise in ovaries, pancreas and appendix, but there have been occasional reports in many other locations. Most retroperitoneal and mesenteric mucinous cystadenomas have affected women, and a potential mullerian origin has been postulated, although for most of them their histogenesis remains uncertain. Some cases have shown malignant behavior. We herein describe a case of mucinous cystadenoma affecting a young man with an unusual prerectal location. An exhaustive study was performed as a basis for the discussion of possible origins for this tumor. This lesion showed premalignant proliferative changes, suggesting an early stage in a potential malignant transformation. DOI: 10.21276/APALM.1453

Highlights

Mucinous cystadenoma usually arise in ovaries, pancreas and appendix, but they have been reported in many other locations.[1]
We describe a case of mucinous cystadenoma affecting a young man with an unusual prerectal location
The histopathological image was in all aspects similar to that seen in appendicular or ovarian mucinous cystadenoma with some features of the so-called borderline lesions in this group.[4]

Summary

Introduction

Mucinous cystadenoma usually arise in ovaries, pancreas and appendix, but they have been reported in many other locations.[1]. We describe a case of mucinous cystadenoma affecting a young man with an unusual prerectal location This lesion showed proliferative changes, suggesting an early stage in a potential malignant transformation. The inner wall was partially denuded of epithelium, but in some areas it showed a well-preserved layer of columnar tall cells (Figure 2a). These cells were relatively uniform and showed mucin production, mainly in the apical cytoplasm. Proliferative index with Ki67 (Figure 3b) was very low and restricted to the basal layer of cells in the foci of pseudostratification, suggesting a benign nature of the lesion.

Discussion

Conclusion