Preperimetric glaucoma

N A Bakunina,I V Shaposhnikova,E V Openkova,L M Gabdrakhmanov,А V Seleznev,H Y Zargaryan,A V Kuroyedov

doi:10.21516/2072-0076-2021-14-1-89-95

Abstract

Recently, much literature data is available on the issue of diagnosis of preperimetric glaucoma (PPG), but no recognized algorithms of detecting primary open-angle glaucoma (POAG) at this stage have been developed, and there is no general opinion as to what parameters and techniques should be used. The review offers a generalization of the literature data on PPG diagnosing and specifies the main parameters that should be taken into account in testing POAG patients at the early preperimetric stage. As is known, the diagnosis of glaucoma is based on detectable changes in the optic nerve head and visual field, but the onset of the disease occurs long before the above changes. Currently, the approach shifts towards early OCT diagnosis of glaucoma. Cohort studies show that structural disorders are detected 5–12 years earlier than functional ones in 17–60 % patients with POAG.

Highlights

Much literature data is available on the issue of diagnosis of preperimetric glaucoma (PPG), but no recognized algorithms of detecting primary open-angle glaucoma (POAG) at this stage have been developed, and there is no general opinion as to what parameters and techniques should be used
The review offers a generalization of the literature data on PPG diagnosing and specifies the main parameters that should be taken into account in testing POAG patients at the early preperimetric stage
Термином препериметрической глаукомой (ППГ) обозначают глаукому, при которой имеются структурные нарушения диска зрительного нерва (ДЗН) или изменения поля зрения (ПЗ), выявляемые с помощью коротковолновой сине-желтой автоматической периметрии (SWAP, Short Wavelength Automated Perimetry) или периметрии с удвоенной частотой (FDT, frequency doubling technology perimetry), в то время как показатели обычных методов периметрии (HFA, Octopus) остаются нормальными [9]

Summary

Introduction

Much literature data is available on the issue of diagnosis of preperimetric glaucoma (PPG), but no recognized algorithms of detecting primary open-angle glaucoma (POAG) at this stage have been developed, and there is no general opinion as to what parameters and techniques should be used. Что у 17–60 % пациентов с ПОУГ структурные нарушения (повреждения ганглиозных клеток сетчатки, ГКС) обнаруживаются на 5–12 лет раньше, чем функциональные (характерные для глаукомы дефекты ПЗ) [3, 4]. [14] с помощью ОКТ высокого разрешения (Cirrus HDOCT, Zeiss) не обнаружили разницы в толщине комплекса ГКС у пациентов с ППГ и лиц группы сравнения, тогда как параметры ДЗН и толщина перипапиллярного СНВС во всех секторах достоверно отличались (р < 0,001).

Results

Conclusion