Preparing for the Next Epidemic with Basic Virology.

Michael S Diamond

doi:10.1371/journal.ppat.1005182

Abstract

Preparing for the Next Epidemic with Basic Virology.

Highlights

I have found that obtaining fundamental insights into how one virus “works” enables the study of other viruses, which has allowed my group to investigate basic principles of viral pathogenesis and host immune restriction
In the late 1990s, as a postdoctoral fellow in Eva Harris’ laboratory, I began working at the bench in virology by studying virus–host cell interactions of Dengue virus (DENV), a mosquito-transmitted flavivirus responsible for considerable morbidity on a global scale
Beyond learning molecular virology and fundamental principles of the viral life cycle in the host, I became interested in defining mechanisms of host immune restriction, viral immune evasion, and viral pathogenesis

Summary

Introduction

I have found that obtaining fundamental insights into how one virus “works” enables the study of other viruses, which has allowed my group to investigate basic principles of viral pathogenesis and host immune restriction. In the late 1990s, as a postdoctoral fellow in Eva Harris’ laboratory, I began working at the bench in virology by studying virus–host cell interactions of Dengue virus (DENV), a mosquito-transmitted flavivirus responsible for considerable (and growing!) morbidity on a global scale.

Results

Conclusion