Abstract
A method is described that separates taxane compounds from crude extracts under either reversed- or normal-phase conditions using a Zorbax-based bonded material, “SW-Taxane”. A crude plant extract of Taxus canadensis and five standard taxane compounds were separated. The method provides high selectivity and recoveries of compounds from a taxol extract in the isocratic mode. Under normal-phase conditions, the packing material has shown significantly greater selectivity of taxol-related compounds than bare silica and most other commercially available silica-based bonded materials. Reversed-phase separations on the column, are also superior compared to typical C 8 separations. In addition, a loading study demonstrates that this phase has a high taxol saturation capacity due to its large surface area.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
