Abstract

Several chromatographically developed chiral selectors show promise for large scale separation of enantiomers using hollow-fiber membrane technology. Chiral selectors derived from N-(1-naphthyl) leucine have been used in a hollow-fiber membrane system (Sepracor) to separate the enantiomers of amino acid derivatives. Enantiomeric purities exceeding 95% have been obtained in a single pass through the system. For data collection, sample sizes were limited to giam quantities of racemate.

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