Abstract
ABSTRACT The convergent synthesis of poly(benzyl ether) dendrimers was published by Frechet et al.[1] However, the coupling of the lower generation bromide with the 3,5-dihydroxy benzyl alcohol (monomer) involved the use of triphenylphosphine. The purification of higher generation dendrimers was difficult because triphenylphosphine was not easily separated from the desired product. A different approach was studied in our laboratory. A mesylate intermediate was developed, followed by the coupling of the monomer. Dendrimers generated from this process were separated using preparative LC chromatography. Non-porous silica (NPS) chromatography methods were developed to monitor the mesylation.[2] and coupling reactions and to confirm the purity of the preparative chromatography fractions.
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