Abstract
SUMMARYPreparation is given and metabolic fate is shown in rats for both fatty‐acid‐V‐labeled and polyoxyetbylene‐C14‐labeled polyoxyethylene (20) sorbitan monolaurate. The emulsifier's metabolic pattern, following oral administration, appears to be as follows: The ester bond between the polyoxyethylated polyol and fatty acid moieties undergoes almost complete hydrolysis, with the fatty acid portion being metabolized in a manner similar to that for trilaurin. The ether linkage between the polyoxyethylene chain and the hexitan molecule is not disrupted appreciably, and this polyoxyethylene‐polyol emulsifier moiety is only slightly absorbed. The data also show that none of the polyol moiety is stored in the body of the animal. The fate of each labeled form of the emulsifier following intravenous administration is also shown.
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