Preparations and Comparison of the Efficacy of a Combination Topical Solution of Erythromycin 3% with Salicylic Acid 2% Versus Clindamycin 3% with Salicylic Acid 2% in the Treatment of Acne Vulgaris

Abstract

The overall response in both therapeutic combinations were relatively with equal effect. In the first group, 45.7% of patients were cured and relapse was seen in 14.2% of the patients and no patients develop worse subsequent relapse. In the second group, the cure rate was 47 and relapse recorded in 11.4% with no development of worse course. While in third group none patients cured during the treatment course duration and the worsen clinical status developed in 77.1% of the patients. Mild skin irritation, redness, dryness and itching were developed as adverse effects in 91.4% of patients in the first 5 minutes of drugs application in group A and B. Dryness developed in 20% of the placebo group. However, the treatment was well tolerated in patients receiving active treatments