Abstract
<p indent=0mm>It is a hot topic in science nowadays and of great practical significance for developing abundant green natural resources and their applications in the research of biomedicine and tissue engineering. This article successfully prepared the biocompatible and biodegradable soy protein and silk fibroin composite nanofiber membrane by spinning technique. The apparent morphologies, structural changes and interactions of the two materials were characterized by scanning electron microscopy, Raman and Fourier transform infrared spectroscopy and X-ray diffraction. Differential scanning calorimetry and thermogravimetric analysis were used to investigate the blending properties of the two phases. The water retention, <italic>in vitro</italic> degradation, and cytocompatibility of the composite films were also evaluated. The results showed mainly hydrogen bond interactions between silk fibroin and soy protein molecular chains, which had thermodynamic compatibility and showed good morphology and thermal properties of nanofibers. With the increase of soybean protein content, the <italic>β</italic>-sheet content of the composite nanofiber membrane increases gradually. At the same time, the glass transition temperature decreases, the specific heat capacity increases a little more, and the water retention ability increases as well as the enzymatic degradation speed. Simultaneously, compared with pure silk fibroin, soy protein/silk fibroin composite nanofiber membrane can provide a better environment for cell adhesion and proliferation, which can be used as a wound dressing and drug delivery system. Especially, the composite fiber membrane containing 60% soy protein showed the strongest cell activity. This study provides a new view for preparing natural materials such as silk fibroin and soy protein and supplies the experimental and theoretical basis for the wide applications of green natural resources.
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