Abstract
Abstract Nucleophilic substitution at tetracoordinated phosphorus centers has been extensively investigated.1 Transesterification of acyclic phosphinates proceeds with inversion of configuration,2 whereas four-membered phosphinates react with retention.3 In previous work4 we suggested that transesterification in six-membered phosphinates occurs via an SN2 mechanism. The title compound was synthesized as a model structure to study the stereochemical and mechanistic aspects of nucleophlic substitution at phosphorus in a six-membered ring. A mixture of diastereomers was produced and separated by column chromatography. Both the mixture and separate isomers were used for an investigation of substitution with methanol, methoxide ions, and phenoxide ions; the reactions proceeded with inversion. Transesterification reactions of the resulting thiophosphinates were studied and found to proceed with inversion. Reactions of these with phenyllithium, benzyllithium, lithium phenylacetylide, and the corresponding organo...
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
