Abstract
Little work has been done on the chemical and physical properties of brain nuclear DNA. Recently Du Buy, Mattern and Riley (1966) described the heat denaturation of mouse brain nuclear DNA, which apparently differs from the related mitochondrial DNA and the various protozoal DNA's tested. For such studies, it is essential to prepare the nuclear DNA from brain tissues in a native and highly polymerized state. In this brief communication preparation procedures of the native DNA from isolated brain nuclei are described, and some physical and chemical properties are given.
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