Abstract
A Schiff base (SB) derived from p-hydroxy benzaldehyde and 4-aminobenzoic acid. The transition metal complexes of Ni (II), Cu (II), Co (II), Cd (II), Zn (II) and Cr (III) were prepared separately with the Schiff base (SB), which were used as ligand. Several physical tools, in particular; elemental analysis, molar conductivity, magnetic susceptibility, infrared spectroscopy (IR), electronic absorption spectroscopy (ESR) to investigate the chemical structure of the prepared transition metal complexes. The elemental analysis data show the formation of 1:2 [M1:2L] and 1:3 [M2:3L] complexes of the formula of M2+L2 and M3+L3, respectively where M2+ =Ni (II), Cu (II), Co (II), Cd (II), Zn (II) and M3+= Cr (III) and L = Schiff base (SB). The molar conductance (conductivity) measurements were revealed that all the complexes are nonelectrolyte in nature. The infrared (IR) spectral studies indicated the binding sites of the Schiff base ligand with the transition metal ions. The magnetic susceptibility measurements and electronic spectral results supported the predicted coordination geometry of the complexes and magnetic properties (para or dia-magnetic nature) of the complex compounds. The free Schiff base and its complexes have been tested for their antimicrobial activities against several human pathogenic (two gram-positive and two gram-negative) bacteria. The obtained results showed that the complex compounds exhibit moderate to strong antimicrobial activity compared with kanamycin and ampicillin.
Highlights
Schiff bases were first discovered by a German chemist, Nobel Prize winner, Hugo Schiff
The elemental analysis and physical properties of the complexes are listed in Table 1 and Table 2
The results revealed that among all the tested samples, these metal complexes showed strong activity against both the Gram positive and Gram-negative bacteria
Summary
Schiff bases were first discovered by a German chemist, Nobel Prize winner, Hugo Schiff. Para-hydroxy benzaldehyde and 4aminobenzoic acid compounds are capable to form complexes with transition metal ions in the form of Schiff bases. A large number of the metal complexes with different electronic structures have been synthesized using Schiff base ligands [9,10,11,12]. It was observed that the complexes have potential antimicrobial activity Keeping these facts in view the significance of metal in biology, we here in report the synthesis of the Schiff base by the condensation of p-hydroxy benzaldehyde and 4-aminobenzoic acid and complexation this Schiff base with several transition metals Ni (II), Cu (II), Co (II), Cd (II), Zn (II) and Cr (III) ions. The antimicrobial activities of these complexes were reported here
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