Abstract
198Au(I)-labelled gold-chloroquine complex [ 198 Au(PPh 3 )(CQ)]PF 6 has been prepared for the enhancement of antimalarial action against chloroquine-resistant strains of Plasmodium falciparum of recently reported [Au(PPh 3 )(CQ)]PF 6 . [ 198 Au(PPh 3 )(CQ)]PF 6 was synthesized via 3-step route starting with irradiated in the reactor for 2 hours Au foil and purified on Sep-Pak® Cl cartridge. Specific activity of the complex was 1.5 mCi/mg. The possibility of using metal complexes radiolabelled with therapeutic radioisotopes for treatment of chloroquine-resistant malaria is discussed.
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