Preparation of zwitterionic random and block poly(N-α-acrylamide-l-lysine-co-2-methacryloyloxyethyl phosphorylcholine) copolymers and their effect on fibrinolytic activity

Abstract

We have developed N-α-lysine acrylamide (LysAA) with a lysine side chain that enhances the fibrinolytic system; random copolymerization of LysAA with MPC [20% molar ratio] enhanced the fibrinolytic activity of LysAA.