Preparation of Veterinary Premix with Dual Active Ingredients in Granular Form

Andrea Fodor-Kardos,Judit Tóth,Aurél Ujhidy,Béla Gyetvai,Gábor Nagy

doi:10.3311/ppch.18703

Abstract

The aim of the study was to investigate the preparation of granular veterinary premix containing two different antibiotics by fluid bed granulation process. The particle size and density of the active ingredients were investigated for the proper selection of the filler material. The used antibiotics were tylosin tartarate and colistin sulfate, while isomalt sugar alcohol and cellulose materials were selected as filler and binder, respectively. The colistin sulfate was fed together with the binder solution because of its low density, fine particle size and relatively low (1.2%) concentration in the product. The type and concentration of the binder in its solution, the feeding rate and the total amount of added binder solution were optimized for obtaining dust free granules with desirable abrasion resistance and good flowability. The active ingredient content for both antibiotics was preserved even at the elevated temperature applied during the fluid granulation process.

Highlights

Veterinary premix is a mixture containing one or more active substances and must always be mixed with animal feed before use
The aim of the study was to investigate the preparation of granular veterinary premix containing two different antibiotics by fluid bed granulation process
The used antibiotics were tylosin tartarate and colistin sulfate, while isomalt sugar alcohol and cellulose materials were selected as filler and binder, respectively

Summary

Introduction

Veterinary premix is a mixture containing one or more active substances and must always be mixed with animal feed before use. Dust is defined as any solid material usually having a particle size less than 100 μm [1]. Dust in premixes increases the cost of medicated feed concerning clean up time of mixing equipment and loss of product. Dust of active ingredients can be irritant and toxic when they get in contact with the operators. They can be harmful to skin, eyes or even to respiratory system. Other possibility is to produce premixes by granulation that is a suitable process for production of particulate materials without dust fraction. Granulation is a size enlargement unit operation where fine particles are agglomerated to form larger granules [3]

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