Preparation of thyme oil loaded κ-carrageenan-polyethylene glycol hydrogel membranes as wound care system

Abstract

The present study is aimed at fabricating thyme oil loaded hydrogel membranes composed of κ-carrageenan (CG) and polyethylene glycol (PEG), which can provide moist environment and prevent infections for rapid wound healing. Membranes were prepared with different amounts of PEG via solvent casting technique under ambient conditions. Physicochemical properties of CG-PEG membranes as a function of the PEG content were investigated. The surface morphology of membranes displayed smoother surfaces with increasing PEG content up to 40%. In addition, the interaction of PEG with CG polymer chains was evaluated in terms of Free and bound PEG fraction within the membrane matrix. Furthermore, thyme oil (TO) was added to enhance the antibacterial properties of CG-PEG membranes. These membranes showed >95% antimicrobial activity against both gram-positive and gram-negative bacteria depending on the TO content. Suggesting the great potential of these membranes as a strong candidate for providing an effective antimicrobial nature in human healthcare.