Abstract
Nickel nanoparticles (Ni-NPs) were synthesized by the reduction reaction of NiCl2·6H2O, N2H4·H2O and NaOH, and then the graphene layers were coated on the surface of Ni-NPs by the carbide cladding method while triethylene glycol was used as carbon source. After etching Ni, the obtained 3D hollow graphene balls (HGBs) were sprayed onto the ITO coated glass to fabricate 3D HGBs/ITO electrode, which acted as a working electrode for determining dopamine and uric acid simultaneously. The results indicate that the multi-layered 3D HGBs maintain the original size of Ni-NPs (the diameter of ~ 100 nm) and have few defects. The 3D HGBs/ITO electrode exhibits a high sensitivity of 1.16 and 0.94 μA μM− 1 for detecting dopamine and uric acid, respectively. Also, it shows a low measured limit of detection, excellent selectivity, reproducibility and stability. It is potential for use in clinical research.
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