Abstract
To develop a new drug delivery matrix with the suitable responsive interval, a well-defined triblock copolymer MPEG-b-PNIPAM-b-MPEG was synthesized by reversible addition fragmentation chain transfer (RAFT) polymerization. Then, the supramolecular hydrogels were fabricated via inclusion complexation with α-cyclodextrin (α-CD) and the triblock copolymers in aqueous solutions. The triblock copolymers were characterized by 1H NMR and gel permeation chromatography (GPC), and the supramolecular structures of hydrogels was confirmed by DSC. The resultant hydrogels was found to be thermo-sensitive, and the response interval could be modulated by controlling the content of PNIPAM.
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