Year-end Sale % OFF 
Abstract
The [ 11C]carbonation of simple Grignard reagents (RMgX, R = Et, Pr, cyclo-Bu; X = Br) with cyclotron-produced [ 11C]carbon dioxide followed by direct treatment of the 11C adducts with phthaloyl dichloride and 2,6-di-t-butylpyridine affords [1- 11C]acid chlorides in useful radiochemical yields (> 10–30%, decay-corrected from 11CO 2), as assessed by HPLC and TLC of the labelled amides formed by reaction with 1,2,3,4-tetrahydroisoquinoline. With suitable precuations these [1- 11C]acid chlorides can be isolated at high specific activity within 15 min from radionuclide production as labelling agents for potential radiopharmaceuticals for PET. The preparation of [1- 11C]benzoyl chloride without isolation has also been demonstrated.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: International Journal of Radiation Applications & Instrumentation. Part A, Applied Radiation & Isotopes
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
