Abstract
Abstract Boronic acid-grafted amphiphilic poly(γ-glutamic acid) was successfully synthesized with carbodiimide. These copolymers could form 200-nm-sized monodispersed nanoparticles (NPs). These NPs were stable in saline and could efficiently load small interfering RNA (siRNA) in a dose-dependent manner at about 80% efficiency. These results demonstrated that the polymer chemistry could contribute to the development of siRNA-based gene therapies.
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