Abstract
2-Amido-pyrazine (AP) is a well-known antitubercular drug [1]. Pyrazine 2,3-dicarboxylic acid is an important intermediate in the preparation of AP. Its preparation involves the oxidation of quinoxaline by potassium permanganate to yield pyrazine 2,3dicarboxylic acid (PDA). The reaction conditions are such that the diacid produced is present as potassium salt along with potassium carbonate. The use of electrodialysis in the pharmaceutical and food industry for the separation of salts, acids and bases from aqueous solutions is of recent origin [4]. Electrodialysis is also used in the purification of organic acids [5-10]. In the present work, we describe the use of electrodialysis for the preparation of PDA from an aqueous solution containing the potassium salt of PDA and potassium carbonate.
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