Abstract
A method was elaborated to obtain “Moricrase”, a complex of collageno and fibrinolytic proteinases from Paralithodes camchatica hepatopancreas. Moricrol, a Moricrase-containing ointment, was shown to exhibit wound-healing activity in the treatment of burns and trophic ulceration as well as postoperative scars. The following homogeneous proteinases were isolated from Moricrase: collagenolytic serine proteinase, trypsin, metalloproteinase, carboxypeptidase, and aminopeptidase. An efficient collagenolytic activity of Moricrase is a result of cooperative action of these enzymes.
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