Preparation of Powdered Redispersible Vitamin E Acetate Emulsion by Spray-Drying Technique.

Abstract

Vitamin E acetate (VEA) was transformed into powdered form by a spray-drying technique and the water dispersible or drug releasing property of the dried particle was evaluated. The powdered VEA was prepared by spray-drying emulsified VEA with colloidal silica (Aerosil 200) and a disintegrant such as low-substituted-hydroxypropylcellulose (L-HPC). VEA in the spray-dried particle was chemically stable in storage longer than three years. On being dispersed in water with gentle shaking, the spray-dried particle released a large number of VEA droplets into the water, which formed a stable emulsion without additional stirring processes. This VEA releasing was mainly due to water uptake and swelling of the disintegrant formulated into the particle. The drug releasing property of the spray-dried particle significantly varied with the type of additives formulated, i.e., surfactant and disintegrant. The constituent ratio of the excipients (Aerosil 200 to disintegrant) influenced not only the VEA releasing but also the flowing property of the spray-dried particle. Based on these findings, an optimum formulation for the powdered VEA with both good drug releasing and flowing properties was established.