Abstract

AbstractTwo N‐methylated derivatives of kanamycin A were synthesized. The first compound, octa‐N‐methylkanamycin, was prepared by reductive methylation of kanamycin A. The second, tetra‐N‐methylkanamycin, was obtained by catalytic debenzylation of tetra‐N‐benzyl‐tetra‐N‐methylkanamycin. Both derivatives were devoid of antibacterial activity.

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