Abstract
Measurement of biologically active compounds in living systems by highly sensitive methods seems to be attractive nowadays. So, design of fluorescence-based quantum dots nanosensors to detect low concentrations of pharmaceutical compounds is a highly attractive area of research. However, reaching the higher fluorescence intensity of quantum dots and reducing the low toxicity of quantum dots by ligand (polymer) exchange method are two more important items. Here, the preparation of novel fluorescence nanosensors κC-CdTe/ZnS quantum dots is reported. After structure confirmation by different analysis methods such as FTIR, TGA, and TEM, fluorescence intensity response of κC-CdTe/ZnS QDs with Epirubicin drug investigated. Based on obtained results, not only this nanosensor developed but also the fluorescence quenching was explained by the typical Stern–Volmer equation. The best linear quenching equation for entitled nanosesor in the presence of Epirubicin is F0/F = 0.0379Q + 1.15 (R2 = 0.99). Moreover, the detection limit of Epirubicin was found around 0.05 × 10−6 mol/L at 25 °C. All of the results showed that this method could be a reliable and suitable approach for the determination of Epirubicin in commercial tablets.
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