Abstract
Large amounts of DNA-enriched biomaterials, such as salmon milts and shellfish gonads, are discarded as industrial waste around the world. We could convert the discarded DNA into a novel bio-matrix by the hybridization of DNA and metal ions, such as Al 3+, Cr 3+, Fe 2+, Fe 3+, Cu +, Cu 2+, Zn 2+, and Cd 2+. These water-insoluble DNA-metal ion matrices could be created in various desirable forms, such as a gel, capsule, film, or fiber. DNA-Al 3+ matrices were found to maintain a B-form DNA structure, which was the native double-stranded DNA structure in water. The DNA-Al 3+ fiber showed flexibility with the molecular orientation in the direction of drawing. When a DNA-Cu 2+ matrix was incubated in an aqueous hydroquinone or ascorbic acid solution, benzoquinone or dehydroascorbic acid was produced, respectively, by the oxidative effect of Cu 2+ in the DNA-metal ion matrix. These results suggest that metal ions in the DNA-metal matrix maintained the oxidative function. The water-insoluble DNA-metal ion matrices may have a potential utility as a functional bio-material, such as an antibacterial, oxidative, bio-sensor, and ion conductive materials.
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