Preparation of nanofibre material based on electrospinning technology and its application in rehabilitation of lower limb joint motion

Abstract

Tissue-engineered muscle keys provide an effective way to solve medical problems such as muscle key defects and muscle leg injuries. Scaffold materials play a key role in tissue engineered muscle bonds. Composite materials are a focus of research on tissue engineered muscle bonds. Nanocomposite fibre membranes with different proportions were successfully prepared by using the lignin-PLA copolymer by electrostatic spinning technology. In vitro experiments have proved that it has obvious cartilage differentiation ability and can repair superficial articular cartilage defects after implantation. Copolymer was successfully synthesised and a series of poly-L-lactide (PLLA)/Lignin nanocomposite fibre membranes were prepared by electrospinning technology. The fibre diameter range was measured from the largest 712 ± 63 nm to the smallest 350 ± 80 nm through material characterisation experiments; the maximum tensile strength 3.49 ± 0.20 MPa, the lowest is 2.49 ± 0.14 MPa; Young's modulus is 56.8 ± 1.6 MPa, the maximum is 66.8 ± 2.8 MPa. This paper provides guidance for innovative composite biomaterials and theoretical basis for the design of cartilage inducing materials.