Abstract
In the present work, linoleic acid and oleic acid were isolated from Indonesian corn oil and palm oil and they were used to prepare monoacylglycerol derivatives as the antibacterial agent. Indonesian corn oil contains 57.74% linoleic acid, 19.88% palmitic acid, 11.84% oleic acid and 3.02% stearic acid. While Indonesian palm oil contains 44.72% oleic acid, 39.28% palmitic acid, 4.56% stearic acid and 1.54% myristic acid. The oleic acid was purified by using Urea Inclusion Complex (UIC) method and its purity was significantly increased from 44.72% to 94.71%. Meanwhile, with the UIC method, the purity of ethyl linoleate was increased from 57.74% to 72.14%. 1-Monolinolein and 2-monoolein compounds were synthesized via two-step process from the isolated linoleic acid and oleic acid, respectively. The preliminary antibacterial assay shows that the 1-monolinolein did not give any antibacterial activity against Staphylococcus aureus and Escherichia coli, while 2-monoolein showed weak antibacterial activity against Staphylococcus aureus.
Highlights
On the other hand, recently, a great concern is on the food sustainability field to ensure food safety and quality for human health[10]
Since Indonesian corn oil and palm oil are rich with linoleic acid and oleic acid content, it is interesting to evaluate monolinolein and monoolein antibacterial activity against S. aureus and E. coli
1-monolinolein and 2-monoolein were prepared from commercially available Indonesian corn oil and palm oil, and their antibacterial activity was investigated against E. coli and S. aureus
Summary
A great concern is on the food sustainability field to ensure food safety and quality for human health[10]. A lot of organic compounds were synthesized or isolated from the natural products and evaluated for their antimicrobial activities They have serious drawbacks, such as high price, limited natural product resources, complicated synthesis route, low security for human health, low physical and chemical stability, etc.[12,13]. Several researchers investigated the antimicrobial activity of fatty acid derivatives. Since Indonesian corn oil and palm oil are rich with linoleic acid and oleic acid content, it is interesting to evaluate monolinolein and monoolein antibacterial activity against S. aureus and E. coli. 1-monolinolein and 2-monoolein were prepared from commercially available Indonesian corn oil and palm oil, and their antibacterial activity was investigated against E. coli and S. aureus. Afterwards, each of them was used to produce monoacylglycerol compound Their antibacterial activity was evaluated against E. coli and S. aureus through well-diffusion method. The effect of the alkyl chain towards its antimicrobial activity is discussed
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