Abstract
As a transdermal drug delivery technology, microneedle array (MNA) has the characteristics of painless, minimally invasive, and precise dosage. This work discusses and compares the new MNA mold prepared by our group using MEMS technology. First, we introduced the planar pattern-to-cross-section technology (PCT) method using LIGA (Photolithography, Galvanogormung, Abformung) technology to obtain a three-dimensional structure similar to an X-ray mask pattern. On this basis, combined with polydimethylsiloxane (PDMS) transfer technology and electroplating process, metal MNA can be prepared. The second method is to use silicon wet etching combined with the SU-8 process to obtain a PDMS quadrangular pyramid MNA using PDMS transfer technology. Third method is to use the tilting rotary lithography process to obtain PDMS conical MNA on SU-8 photoresist through PDMS transfer technology. All three processes utilize parallel subtractive manufacturing methods, and the error range of reproducibility and accuracy is 2–11%. LIGA technology produces hollow MNA with an aspect ratio of up to 30, which is used for blood extraction and drug injection. The height of the MNA prepared by the engraving process is about 600 μm, which can achieve a sustained release effect together with a potential systemic delivery. The height of the MNA prepared by the ultraviolet exposure process is about 150 μm, which is used to stimulate the subcutaneous tissue.
Highlights
One method to produce microneedle arrays (MNA) is micro-electro-mechanical system (MEMS) technology [1,2]
Fabrication Results of Tilting Rotary UV Lithography a conical MNA was fabricated by PDMS transfer technology
This paper introduces three methods for manufacturing MNA based on MEMS technology
Summary
One method to produce microneedle arrays (MNA) is micro-electro-mechanical system (MEMS) technology [1,2]. The MNA form a tiny channel on the surface of the human skin, so that drug can reach the specified depth of the skin, and have the advantages of accurate administration, high efficiency, simple operation, and pain-free [7,8]. It is precisely because of the many superiorities of MNA in TDD that people are constantly exploring and researching the combination of MNA and therapeutics, such as a vaccine, insulin, and low molecular weight heparin. With the development of biomacromolecules and nanomedicines, the demand for transdermal delivery of MNA is increasing, and MNA have broad prospects for development [9,10,11]
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