Abstract
A hexagonal lyotropic liquid crystal (LLC) was constructed with nonionic surfactant Triton X-100 and mixed magnesium chloride/aluminum chloride aqueous solutions. Layered double hydroxide (LDH) nanosheets (L-LDHs) were prepared using the LLC as a microreactor. A nanohybrid material of L-LDHs intercalated with a model anionic drug, diclofenac sodium (DS; DS/L-LDHs) was synthesized using an ion- exchange method. The drug-release profile of DS/L-LDH was investigated under moderate conditions, i.e., 37.0 °C and pH 7.2. The results were compared with those for common LDH flaky particles (S-LDHs) synthesized using a traditional solution coprecipitation method. The crystalline structures, specific surface areas, and morphologies of these LDHs and DS/LDHs nanohybrids were characterized using powder X-ray diffraction (XRD), Fourier-transform infrared (FT-IR) spectroscopy, field-emission scanning electron microscopy (FE-SEM), transmission electron microscopy (TEM), and N2 adsorption-desorption. The results show that the L-LDH
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