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Abstract
With the aim of developing efficient flow-through microreactors for high-throughput organic synthesis, in this work, microreactors were fabricated by chemically immobilizing palladium-, nickel-, iron-, and copper-based catalysts onto ligand-modified poly(glycidyl methacrylate-co-ethylene dimethacrylate) [poly(GMA-co-EDMA)] monoliths, which were prepared inside a silicosteel tubing (10 cm long with an inner diameter of 1.0 mm) and modified with several ligands including 5-amino-1,10-phenanthroline (APHEN), iminodiacetic acid (IDA), and iminodimethyl phosphonic acid (IDP). The performance of the resulting microreactors in Suzuki−Miyaura cross-coupling reactions was evaluated, finding that the poly(GMA-co-EDMA) monolith chemically modified with 5-amino-1,10-phenanthroline as a binding site for the palladium catalyst provided an excellent flow-through performance, enabling highly efficient and rapid reactions with high product yields. Moreover, this monolithic microreactor maintained its good activity and efficiency during prolonged use.
Highlights
High-throughput synthesis is required in the globally competitive life sciences industry, and so far, substantial efforts have been dedicated to the development of high-speed synthesis tools and techniques
We investigated several types ofeffective ligands and catalysts immobilized in the methacrylate-based monolithic for crossMiyaura cross-coupling reaction
We investigated several types of ligands and metal catalysts immobilized in the methacrylate-based monolithic column for an effective cross2
Summary
High-throughput synthesis is required in the globally competitive life sciences industry, and so far, substantial efforts have been dedicated to the development of high-speed synthesis tools and techniques. In this context, microreactors have received considerable interest in organic synthesis due to their effective and efficient chemical reactions, which benefit from their fast kinetic rates, rapid mass transfer, high yields, short reaction times, cost reduction, and low waste production. The presence of residual catalysts in the products can generate problems in the synthesis of functional substrates. Approaches such as the loading of metal catalysts onto carbon [10,11]
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