Abstract
Drug delivery systems (DDSs) limited to a single function or single-drug loading are struggling to meet the requirements of clinical medical applications. It is of great significance to fabricate DDSs with multiple functions such as magnetic targeting or fluorescent labeling, as well as with multiple-drug loading for enhancing drug efficacy and accelerating actions. In this study, inspired by the dual-chamber structure of rapeseed pods, biomimetic magnetic–luminescent bifunctional drug delivery carriers (DDCs) of 1.9 ± 0.3 μm diameter and 19.6 ± 4.4 μm length for dual drug release were fabricated via double-needle electrospraying. Morphological images showed that the rapeseed pod-like DDCs had a rod-like morphology and Janus dual-chamber structure. Magnetic nanoparticles and luminescent materials were elaborately designed to be dispersed in two different chambers to endow the DDCs with excellent magnetic and luminescent properties. Synchronously, the Janus structure of DDCs promoted the luminescent intensity by at least threefold compared to single-chamber DDCs. The results of the hemolysis experiment and cytotoxicity assay suggested the great blood and cell compatibilities of DDCs. Further inspired by the core–shell structure of rapeseeds containing oil wrapped in rapeseed pods, DDCs were fabricated to carry benzimidazole molecules and doxorubicin@chitosan nanoparticles in different chambers, realizing the sequential release of benzimidazole within 12 h and of doxorubicin from day 3 to day 18. These rapeseed pod-like DDSs with excellent magnetic and luminescent properties and sequential release of dual drugs have potential for biomedical applications such as targeted drug delivery, bioimaging, and sustained treatment of diseases.
Highlights
Introductionmagnetic nanoparticles (MNPs) and the other side containing [Eu(BA) phen+Tb(BA) phen] (BA = benzoic acid, phen = 1,10-phenanthroline) by parallel electrospinning, resulting in high luminescence intensity almost unaffected by Fe3 O4 MNPs. In addition to using magnetic or fluorescent materials to enhance targeting efficiency, the regulation of morphology, size, and surface composition of carriers affects the therapeutic effect of Drug delivery systems (DDSs) [13]
Of a new bionic idea structure rapeseedresults pods demonstrated a distinguished effect with the magnetic–luminescent bifunctional and the core–shell structure of rapeseeds containing oil wrapped in rapeseed pods was rapeseed pod-like for sequential release ofofdual drugs
Drug delivery systems (DDSs) with proposed, allowingDDSs the successful establishment magnetic–luminescent excellent magnetic and luminescent properties are highly promising for application in rapeseed pod-like drug delivery carriers (DDCs) for sequential release of dual drugs via double-needle electrospray3+
Summary
MNPs and the other side containing [Eu(BA) phen+Tb(BA) phen] (BA = benzoic acid, phen = 1,10-phenanthroline) by parallel electrospinning, resulting in high luminescence intensity almost unaffected by Fe3 O4 MNPs. In addition to using magnetic or fluorescent materials to enhance targeting efficiency, the regulation of morphology, size, and surface composition of carriers affects the therapeutic effect of DDSs [13]. One chamber contained luminescent NaYF4:Eu3+ NPs and CS NPs, whereas magnetic Fe3O4 MNPs were loaded in another chamber of the DDCs. The dual-chamber structure was expected to reduce the interaction with luminescent material and, enhance luminescent intensity. The sustained release drugs in rapeseed pod-like DDSs showed great utility in continuously inhibiting tumor of drugs in cell growth. Pod-like R2 DDSs for the sequential release of dual drugs
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