Abstract
Solid lipid nanoparticles (SLNs) loaded ginger extract were prepared by microemulsion technique. The nanoparticles were composed of stearic acid as solid lipids, Cremophor RH 40 as surfactant and ethanol as co-surfactant. It was found that variation in the amount of surfactant and co-surfactant had profound effects on the mean particle size, the drug entrapment efficiency and loading capacity. Transmission electron microscope (TEM) revealed the spherical nature of the particles. The mean particle size of SLNs ranging between 453.1 and 551.7 nm were measured by dynamic light scattering (DLS). The entrapment efficiency (EE) and drug loading capacity (LC) determined by high performance liquid chromatography (HPLC) found to be in the range of 85.2390.07% and 1.411.49%, respectively.
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