Abstract
The high viscosity of sodium alginate( ALG) causes its insufficient targeted ligand loading,and further influences the targeted recognition effect of nano-prodrug. Here,oligomeric ethylene glycol modified-sodium alginate( ALG-mOEG) was used as a carrier to improve the targeted-ligands loading. Results showed that ALG-mOEG significantly improved glycyrrhetinic acid( GA) loading compared with unmodified ALG( 11. 8%vs. 6. 9%,1. 97-fold increase). On this basis,the liver targeted nano-prodrug( DOX-ALG-mOEG /GA-ALGmOEG NPs) was self-assembled via dialysis method by mixing GA-ALG-mOEG and DOX-ALG-mOEG. Cell cytotoxicity experiment showed that DOX-ALG-mOEG /GA-ALG-mOEG NPs inhibited HepG2 proliferation with an half maximal inhibitory concentration( IC50) value of 58.1 ng/mL while the IC50 of control group was141. 7 ng /mL; the tumor growth inhibition rate( IR) reached to 88. 4%,improved by 11. 5% compared to that of the control group. This study show that the liver targeted nano-prodrug based on ALG-mOEG can effectively improve the drug utilization,and provide a reference for the preparation of other polysaccharide targeted nanoprodrug.
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