Abstract
ABSTRACTThe growing demand for lipid–polymer conjugates (LPCs) in biomedicine highlights the need for efficient synthesis methods. This study presents a novel Y‐type photoiniferter reagent (Lipid‐PIT) with a diethyldithiocarbamate group and a diacylglycerol group. Lipid‐PIT efficiently initiated the polymerization of vinyl monomers such as oligo(ethylene glycol) methacrylate (OEGMA), N,N‐dimethylacrylamide (DMA), tert‐butyl acrylate (tBA), and n‐butyl acrylate (nBA) under UV irradiation at room temperature, yielding LPCs. Proton NMR confirmed the presence of diethyldithiocarbamate and diacylglycerol moieties at the chain ends. The polymerization kinetics of DMA showed a linear increase in molecular weight (Mn) with time, with a polydispersity (Đ) below 1.50, demonstrating high controllability. Moreover, Lipid‐PIT allows for the creation of block copolymers via secondary chain extension. In vitro assays revealed that LPCs synthesized from OEGMA monomers successfully modified L929 and HeLa cell surfaces and exhibited good biocompatibility. This study offers a rapid, efficient method for LPC synthesis with promising biomedical applications.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
