Abstract

In this study, a lauroyl grafted hydrophobic glycolipid derivative of alginate has been successfully synthesized and characterized. This glycolipid has been incorporated into Psyllium husk gel-alginate composite films and compared with the films containing only Psyllim husk gel and Psyllim husk gel-alginate for its mechanical and physicochemical properties. Additionally, the composite film has also been evaluated for protein adsorption and antimicrobial property to verify its utility in biomedical applications. The results showed that the composite films have enhanced physicochemical and mechanical properties. The film produced better swelling characteristic and lower protein adsorption property indicating the usefulness of the film in wound care dressing, particularly for low suppurating wounds. Incorporation of the synthesised glycolipid derivative also imparts antimicrobial activity to the composite film. Therefore, the developed film is capable of sustaining the microbial contamination during the storage and also valuable in the biomedical utility including wound dressings.

Highlights

  • In this study, a lauroyl grafted hydrophobic glycolipid derivative of alginate has been successfully synthesized and characterized

  • A lauroyl grafted hydrophobic glycolipid derivative of alginate has been successfully synthesized and characterized. This glycolipid has been incorporated into Psyllium husk gel-alginate composite films and compared with the films containing only Psyllim husk gel and Psyllim husk gelalginate for its mechanical and physicochemical properties

  • The composite film has been evaluated for protein adsorption and antimicrobial property to verify its utility in biomedical applications

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Summary

Composite Film with Enhanced

Physicochemical, Mechanical and Antimicrobial Properties Published online: 21 November 2018. A lauroyl grafted hydrophobic glycolipid derivative of alginate has been successfully synthesized and characterized This glycolipid has been incorporated into Psyllium husk gel-alginate composite films and compared with the films containing only Psyllim husk gel and Psyllim husk gelalginate for its mechanical and physicochemical properties. In contrast to sodium alginate, Psyllium is hydrophobic in nature and well known for its gelling capabilities, swelling ability and water uptake properties. These properties are primarily credited to the presence of hyper branched acidic arabinoxylan backbone with both (1–4) and (1–3) linkages as well as high percentage of hemicelluloses[8]. The composite film has been evaluated for protein adsorption study to predict wound adherence and antimicrobial property in order to verify the reduction in the microbial load of the prepared film

Results and Discussion
Conditions Before immersion After immersion
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