Abstract
This study was aimed to produce silver nanoparticles by fruits extract of Juniperus phoenicea and comparison between the ethanolic extract and nano extract through the antioxidant, antibacterial, anti-parasite and cytotoxicity against prostate cancer. The synthesis of silver nanoparticles was shown by many characterizing techniques: UV, FTIR, XRD and SEM. Nano extract exhibited a higher antibacterial, antioxidant, antiparasite compared to ethanolic extract and higher cytotoxicity activity. The nano extract exhibited higher antibacterial activity compared with antibiotics. Finally, we study the toxicity of J. phoenicea by Inhibition of RBC hemolysis by H2O2, the results exhibited the highest inhibition activity of J. phoenicea against H2O2. The nanoextract of J. phoenicea can be used effectively in the production of potential antioxidant, antiparasite antimicrobial and anticancer.
Highlights
Plants were used a source of treatment diseases in most parts of the world [6, 9]
The synthesized silver nanoparticles are characterized by SEM, X-ray diffraction (XRD), UV and FTIR analysis
These poly flavonoids and phenols are used as antioxidant and antimicrobial agents by the plants to protect themselves from several pathological conditions [11, 24]
Summary
Plants were used a source of treatment diseases in most parts of the world [6, 9]. The genus Juniperus followed to Family Cupressaceae [1, 10]. New studies were observed the inhibitory action of Juniperus against Staphylococcus aureus, Escherichia coli, Listeria monocytogenes Bacillus cereus, Cornybacterium spp and with an extended panel of pathogenic bacteria [11,24]. Plant parts such as bark, seed, stem, fruit, and leaf extracts have been successfully used for synthesis of nanoparticles [3]. The present study was aimed to produce silver nanoparticles from fruits extract of Juniperus phoenicea and comparison between the ethanolic extract and nano extract through the antioxidant , antibacterial ,antiparasite and cytotoxicity against prostate cancer cell line in vitro, examiend the combined effect of some antibiotics and nanoextract against some pathogenic bacteria. Was study the toxicity of Juniperus phoenicea by Inhibition of RBC hemolysis caused by H2O2
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