Preparation of Ibuprofen-loaded Geonanohybrids Using a Facile Grinding Process

Abstract

In the present investigation, a controlled release system for ibuprofen was prepared using a newly synthesized nanodrug carrier. The nanodrug carrier was made by blending montmorillonite and chitosan by forming an intimate mixture of geomaterial of montmorillonite clay and chitosan. Ibuprofen was then loaded into the montmorillonite-chitosan nanohybrid and the resulting montmorillonite-chitosan/ibuprofen nanoparticles were characterized using Fourier-transform infrared spectroscopy, X-ray diffraction, thermogravimetric analysis and transmission electron microscopy. The in vitro release profiles of ibuprofen from montmorillonite-chitosan/ibuprofen was studied at 37º±0.5º under simulated gastric and intestinal media at pH 1.2 and pH 7.4, respectively. Controlled drug release was observed at both pH conditions. Kinetic of the release of ibuprofen at pH 1.2 and 7.4 was studied to find that the release followed Korsmeyer-Peppas and first-order kinetic models, respectively.