Abstract
Safely-injectable suspensions of human serum [ methyl- 11C]methylalbumin microspheres have been prepared via the reaction of human serum albumin microspheres with [ 11C]methyl iodide, itself prepared in a novel one-pot synthesis from cyclotron-produced [ 11C]carbon dioxide. The preparation takes only 30 min from the end radionuclide production and proceeds in 22% radiochemical yield based on the activity of [ 11C]carbon dioxide used and decay-corrected. It has been shown that such microspheres are highly stable in vivo and may be used as reference blood flow markers in positron emission tomography (PET). Similarly, safely-injectable and radiochemically pure solutions of human serum [ methyl- 11C]methylalbumin have been prepared in 31% radiochemical yield and in 40 min from the end of [ 11C]carbon dioxide production via the reaction of [ 11C]methyl iodide with human serum albumin. This radiopharmaceutical is intended for studies of lung permeability and blood-brain barrier permeability by PET.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: The International Journal Of Applied Radiation And Isotopes
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
