Abstract
A new method for preparing hydrophilic, cross-linked, solid gelatin microspheres of 15–28 μm size has been developed. Two main advantages of this method are the addition of the cross-linking agent in an organic medium to the aqueous gelatin medium and the use of concentrated high polymer solutions as the organic phase for polymeric dispersions. Gelatin microspheres containing bleomycin were prepared by this novel method using concentrated solutions of polymethylmethacrylate.
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