Abstract
As one of the new anti-tumor methods, drug delivery systems have received extensive attention from researchers. In this study, by the seed anisotropic growth method, with spherical TiO2 as the core, rod-shaped mesoporous silica was grown on the surface of TiO2 in anisotropic manner to prepare ball-rod structure TiO2&mSiO2. Through the surface functional modification method, folic acid is used as the targeting group and doxorubicin hydrochloride (DOX) as the target drug to construct a functionalized redox stimulus-responsive TiO2&mSiO2 drug delivery system. Structure characterization by methods such as SEM, TEM, BET, XRD and FT-IR. In vitro drug release experiments, hemolysis experiments, and cytotoxicity experiments on HeLa cell line confirmed that the drug delivery system has good biocompatibility and GSH concentration-dependent drug release behavior. Cell uptake experiments and apoptosis experiments show that the system has good cell penetration behavior. The prepared redox TiO2&mSiO2 drug delivery system provides a new idea for the clinical treatment of tumors.
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