Abstract
SUMMARY A chicken-embryo-dermis (CED) cell-culture system derived from the skin of a specific-pathogen-free embryo is defined and shown to be highly susceptible to the fowl pox virus (FPV). The high susceptibility of the system and the growth characteristics of the virus suggest that the host-tissue specificity for FPV persists after the cells have differentiated in cell cultures. The cell system consists of cell strains derived from primary CED cell cultures. A vaccinal strain of FPV of Canadian origin (CFPV) was adapted to the cell system, and an experimental batch of vaccine was prepared from the 5th passage and tested. The cell-culture vaccine has higher biological properties than a conventional CFPV vaccine prepared on the chorioallantoic membrane of embryonated eggs. The advantages of the cell-culture FPV vaccine are discussed. The behavior and requirements of the CED cell system are described.
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