Abstract
The synthesis of the Re (V) complex and preparation of 188 Re -AEDP are described using 188 Re which was obtained from the alumina-based 188 W/ 188 Re generator. Dependence of the radiolabeling yields of 188 Re -AEDP on reducing agent concentration, AEDP concentration, pH and addition of carrier was examined. In the case of optimum conditions, the radiolabeling yields of 188 Re -AEDP were 92–93% for carrier-free 188 Re and 95–98% for carrier-added 188 Re . The stability of 188 Re -AEDP at pH≈6 was studied and it is found that the carrier has a significant effect on the stability of 188 Re -AEDP. The biodistribution of carrier-free and carrier-added 188 Re -labelled compounds in rats was also measured. The results show that 188 Re (carrier-added)-AEDP is a potential bone palliation radiopharmaceutical due to its high skeletal uptake, rapid blood clearance and relatively low soft tissue absorption.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
